# Quickstart¶

## Installation¶

Install via pip (see its documentation if it is not yet installed on your system):

pip install lifelines


## Kaplan-Meier and Nelson-Aalen¶

Let’s start by importing some data. We need the durations that individuals are observed for, and whether they “died” or not.

from lifelines.datasets import load_waltons
df = load_waltons() # returns a Pandas DataFrame

"""
T  E    group
0   6  1  miR-137
1  13  1  miR-137
2  13  1  miR-137
3  13  1  miR-137
4  19  1  miR-137
"""

T = df['T']
E = df['E']


T is an array of durations, E is a either boolean or binary array representing whether the “death” was observed (alternatively an individual can be censored).

Note

By default, lifelines assumes all “deaths” are observed.

from lifelines import KaplanMeierFitter
kmf = KaplanMeierFitter()
kmf.fit(T, event_observed=E)  # or, more succiently, kmf.fit(T, E)


After calling the fit method, we have access to new properties like survival_function_ and methods like plot(). The latter is a wrapper around Panda’s internal plotting library.

kmf.survival_function_
kmf.median_
kmf.plot()


### Multiple groups¶

groups = df['group']
ix = (groups == 'miR-137')

kmf.fit(T[~ix], E[~ix], label='control')
ax = kmf.plot()

kmf.fit(T[ix], E[ix], label='miR-137')
kmf.plot(ax=ax)


Similar functionality exists for the NelsonAalenFitter:

from lifelines import NelsonAalenFitter
naf = NelsonAalenFitter()
naf.fit(T, event_observed=E)


but instead of a survival_function_ being exposed, a cumulative_hazard_ is.

Note

Similar to Scikit-Learn, all statistically estimated quantities append an underscore to the property name.

## Getting Data in The Right Format¶

Often you’ll have data that looks like:

start_time, end_time

Lifelines has some utility functions to transform this dataset into duration and censorship vectors:

from lifelines.utils import datetimes_to_durations

# start_times is a vector of datetime objects
# end_times is a vector of (possibly missing) datetime objects.
T, E = datetimes_to_durations(start_times, end_times, freq='h')


Alternatively, perhaps you are interested in viewing the survival table given some durations and censorship vectors.

from lifelines.utils import survival_table_from_events

table = survival_table_from_events(T, E)

"""
removed  observed  censored  entrance  at_risk
event_at
0               0         0         0       163      163
6               1         1         0         0      163
7               2         1         1         0      162
9               3         3         0         0      160
13              3         3         0         0      157
"""


## Survival Regression¶

While the above KaplanMeierFitter and NelsonAalenFitter are useful, they only give us an “average” view of the population. Often we have specific data at the individual level, either continuous or categorical, that we would like to use. For this, we turn to survival regression, specifically AalenAdditiveFitter and CoxPHFitter.

from lifelines.datasets import load_regression_dataset



The input of the fit method’s API in a regression is different. All the data, including durations, censorships and covariates must be contained in a Pandas DataFrame (yes, it must be a DataFrame). The duration column and event occured column must be specified in the call to fit.

from lifelines import CoxPHFitter

# Using Cox Proportional Hazards model
cph = CoxPHFitter()
cph.fit(regression_dataset, 'T', event_col='E')
cph.print_summary()

"""
n=200, number of events=189

coef  exp(coef)  se(coef)      z      p  lower 0.95  upper 0.95
var1 0.2213     1.2477    0.0743 2.9796 0.0029      0.0757      0.3669  **
var2 0.0509     1.0522    0.0829 0.6139 0.5393     -0.1116      0.2134
var3 0.2186     1.2443    0.0758 2.8836 0.0039      0.0700      0.3672  **
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Concordance = 0.580
"""

cph.plot()


If we focus on Aalen’s Additive model,

# Using Aalen's Additive model

Like CoxPHFitter, after fitting you’ll have access to properties like cumulative_hazards_ and methods like plot, predict_cumulative_hazards, and predict_survival_function. The latter two methods require an additional argument of individual covariates:
X = regression_dataset.drop(['E', 'T'], axis=1)

aaf.plot()